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Sirtris Pharmaceuticals has raised a total of $82M in funding over 4 rounds. The Company discovers and develops proprietary, orally available, small molecule drugs. Sirtris Pharmaceuticals is a biopharmaceutical company focused on discovering and developing proprietary, orally available, small molecule drugs … See reviews, photos, directions, phone numbers and more for Sirtris Pharmaceuticals Inc locations in Cambridge, MA. Products; Resources; My Account; Talk to a D&B Advisor 1-800-280-0780. Business Directory. Sirtris Pharmaceuticals Inc., a biopharmaceutical company engaged in developing small molecule drugs that target the sirtuins, a recently discovered family of seven enzymes associated with the aging process, was acquired by GlaxoSmithKline (NYSE: GSK) in June of 2008 and now operates as the company’s wholly-owned subsidiary. [15][16] The company said at that time that it was focused on two compounds called SRT2104 and SRT2379 that were not resveratrol analogs, had better drug-like qualities, and were more selective SIRT1 activators. Sirtris Pharmaceuticals develops small molecule drugs for the treatment of aging and metabolic diseases. Discovery Reveals Critical Role of SIRT3 and SIRT4 in Cell Metabolism. CLAIM THIS BUSINESS. [15][16], In 2013 GSK shut down Sirtris and its development candidates were absorbed into GSK, where research and development continued. Sirtris Pharmaceuticals is a biopharmaceutical company developing and commercializing novel therapeutics that modulate sirtuins, a recently discovered family of enzymes that promotes the body's natural defense against disease. [1], The company was specifically focused on resveratrol formulations and derivatives as activators of the SIRT1 enzyme; Sinclair became known for making statements about resveratrol like: “(It's) as close to a miraculous molecule as you can find.... One hundred years from now, people will maybe be taking these molecules on a daily basis to prevent heart disease, stroke, and cancer.”[1] Most of the anti-aging field was more cautious, especially with regard to what else resveratrol might do in the body and its lack of bioavailability. In most courses studied at Harvard Business schools, students are provided with a case study. [15][16] GSK said it was terminating SRT501 due to side effects of nausea, vomiting, and diarrhea it caused, and because the compound's activity wasn't specific to SIRT1, at some doses it actually inhibited SIRT1, and the compound itself wasn't patentable. [1][3] The company's initial product was called SRT501, and was a formulation of reservatrol. Thomas Salzmann is Former Chairman at Satori Pharmaceuticals Inc. See Thomas Salzmann's compensation, career history, education, & memberships. In 2008, GlaxoSmithKline (GSK) purchased Sirtris Pharmaceuticals for $720 million in order to continue to expand its portfolio of potential drugs to be commercialized in the future. Sirtris Pharmaceuticals has established a drug discovery capability to exploit sirtuin modulation for the treatment of human disease, an approach that has the potential to generate multiple clinically and commercially important products. Sirtris Pharmaceuticals is registered under the ticker NASDAQ:SIRT . The research is at a very early stage and it may take years before the drug could be submitted for approval. The firm is mulling to relocate some of the 60 staffers currently working at the site in Cambridge to Philadelphia office. Their stock opened with $10.00 in its May 23, 2007 IPO. Medvedik has worked as a biotechnology consultant at Sirtris Pharmaceuticals and has taught molecular and synthetic biology to hundreds of students while at Harvard University, The Cooper Union, School of Visual Arts, Genspace and NYU. Sirtris Pharmaceuticals has established a drug discovery capability to exploit sirtuin modulation for the treatment of human disease, an approach that has the potential to generate multiple clinically and commercially important products. Sirtris Pharmaceuticals, Inc. specializes in Pharmaceutical Preparations. David Sinclair Harvard Medical School Department of Pathology NRB, 9 th Floor 77 Avenue Louis Pasteur Boston, MA 02115. SaaS, Android, Cloud Computing, Medical Device), Where the organization is headquartered (e.g. Sirtris Pharmaceuticals Products Add Product. Pathway-oriented platforms are rare, and dealmaking around them can be complicated: partner too early or for too little and you risk giving away the store. See Appendix for pictures of the covers of the Wall Street Journal and Fortune. [6], Studies published in 2009 and early 2010 by scientists from Amgen and Pfizer cast doubt on whether SIRT1 was directly activated by resveratrol and showed that the apparent activity was actually due to a fluorescent reagent used in the experiments. New Pathway for Developing Treatments for Diseases of Aging. Advantages of Living in America. Sirtris Pharmaceuticals is funded by 10 investors. GlaxoSmithKline (NYSE: GSK) has announced that it has entered into a definitive acquisition pact with Sirtris Pharmaceuticals Inc. (NASDAQ: SIRT). Sirtris Pharmaceuticals: Living Healthier, Longer by Toby Stuart , David Kiron , (No reviews yet) Write a Review Consultant to the CEO Jan 2004 to Jan 2006 Kevin Bitterman. Whether any of those compounds are going to be tested on Parkinson’s disease is yet to be determined. Dr. David Sinclair is co-founder of several biotechnology companies (Sirtris Pharmaceuticals, Genocea Biosciences, OvaScience, CohBar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others (most notably Shaklee). "Sirtris is delighted to welcome Mike, who brings to our team a wealth of experience in discovery research, particularly in the metabolic field," said Christoph Westphal, M.D., Ph.D., CEO of Sirtris Pharmaceuticals. GlaxoSmithKline (GSK) is closing its Sirtris Pharmaceuticals office in Cambridge and fully integrating its research and development (R&D) operations with Philadelphia office. Sirtris Pharmaceuticals, Inc. was a biotechnology company based in Cambridge, MA that developed therapies for type 2 diabetes, cancer, and other diseases. The field of sirtuins received high profile exposure last year when GlaxoSmithKline paid $720m to acquire Sirtris Pharmaceuticals, one of the few companies developing a clinical stage pipeline of products which interact with these enzymes which regulate multiple metabolic pathways. Case Description of GSK's Acquisition of Sirtris: Independence or Integration? Describes a set of key strategic decisions facing the scientific founder and CEO of a promising, early stage bio-pharmaceuticals company. [7][8][9][10][11][12], In August 2010, a nonprofit called the Healthy Lifespan Institute, which had been formed the year before by Westphal and Michelle Dipp, who joined GSK from Sirtris, began selling SRT501 as a dietary supplement online;[4] when this become public GSK required Westphal and Dipp, who were still GSK employees, to resign from the nonprofit. Just what did GlaxoSmithKline (GSK) get for its dime when, in 2008, it dropped $720 million (or 72 billion dimes) to buy Sirtris Pharmaceuticals? Sirtris Pharmaceuticals: Living Healthier, Longer Fortune, February 12, 2007. For the biopharma industry investment, business development and competitive intelligence professionals who require information to support financing, partnering and licensing activities, BCIQ provides accurate information and context to support profitable and strategic decision making. Get information, directions, products, services, phone numbers, and reviews on Sirtris Pharmaceuticals in Collegeville, undefined Discover more Pharmaceutical Preparations companies in Collegeville on … ", "Doubts Build On Glaxo's Antiaging Drugs", "Sirtuins: Antiaging Medicines or Marketing? Sirtris Pharmaceuticals has established a drug discovery capability to exploit sirtuin modulation for the treatment of human disease, an approach that has the potential to generate multiple clinically and commercially important products. Sirtris Pharmaceuticals, Inc. – Mergers & Acquisitions (M&A), Partnerships & Alliances and Investment Report Project Synopsis: MarketLine's Company Mergers & Acquisitions (M&A), Partnerships & Alliances and Investments reports offer a comprehensive breakdown of the organic and inorganic growth activity undertaken by an organization to sustain its competitive advantage. Global Market Direct's pharmaceuticals report, "Sirtris Pharmaceuticals, Inc. - Product Pipeline Review - 2013" provides data on the Sirtris Pharmaceuticals, Inc.'s research and development focus. Describes a set of key strategic decisions facing the scientific founder and CEO of a promising, early stage bio-pharmaceuticals company. Health Centers; Information by Medical Specialty; Homepages; Health Websites; Buy Online London-based Glaxo said Tuesday it agreed to buy Sirtris in an all-cash tender offer at $22.50 a share. Solved Sirtris Pharmaceuticals: Living Healthier, Longer (Abridged) case study solution include SWOT Analysis, PESTEL Analysis, VRIO Analysis, Porter Five Forces Analysis & Value Chain Analysis, BCG Growth Share Analysis. Sirtris Pharmaceuticals has established a drug discovery capability to exploit sirtuin modulation for the treatment of human disease, an approach that GSK says has the potential to generate multiple clinically and commercially important products. Should the company establish a proposed alliance with a pharmaceutical firm? See reviews, photos, directions, phone numbers and more for Sirtris Pharmaceuticals Inc locations in Cambridge, MA. GlaxoSmithKline (GSK) to Acquire Sirtris Pharmaceuticals, a World Leader in "Sirtuin" Research and Development for $720M 4/23/2008 LONDON, PHILADELPHIA AND CAMBRIDGE, Mass., April 22 -- Professor Toby Stuart and Senior Researcher Sirtris has already started a larger drug study. The deal is another example of Pharma's interest in platform biotechs and its hunger for innovation. Chemical base materials; Plastic products; Chemical products; Chemical industry plant and equipment; Rubber and plastic industry plant and equipment ; Health, medical and pharmaceutical; Rubber products; Construction. And Sirtris/GSK faces long years of rigorous research before this nook of the anti-aging field yields a marketed drug. [5][17][18] At that time, GSK/Sirtris' lead candidate was SRT2104, described as a "first-generation sirtuin-activating compound. Then in 2013, GlaxoSmithKline shut down Sirtris Pharmaceuticals completely, but indicated that they would be following up on many of Sirtris’s other sirtuins-activating compounds (Click here to read more on this). Private Company Reports provide up to date insight into the structure and operations of privately-held pharmaceutical, biotechnology and biomedical companies.S… The report includes information on current developmental pipeline, complete with latest updates, and features on discontinued and dormant projects. San Francisco Bay Area, Silicon Valley), Operating Status of Organization e.g. Active, Closed, Last funding round type (e.g. Their focus to date has been on the development of SIRT1 activators for the treatment of Type 2 Diabetes Mellitus (T2DM). Sirtris Pharmaceuticals Team Add Team Member. Sirtris Pharmaceuticals Inc. has been sold for $720 million to international pharmaceutical company GlaxoSmithKline (NYSE: GSK), just four years after the biotechnology startup launched. 481 - 490 of 500 . We use cookies to provide you with a better experience. Describes a set of key strategic decisions facing the scientific founder and CEO of a promising, early stage bio-pharmaceuticals company. Multistage venture capital investors with focus Technology, Healthcare and Consumer : United States : 6630 Fund management: edit Explore. Sirtris Pharmaceuticals, Inc. was a biotechnology company based in Cambridge, MA that developed therapies for type 2 diabetes, cancer, and other diseases. PA. Collegeville. Should it create a nutraceuticals business in parallel to its effort to develop anti-aging therapeutics? See Appendix for pictures of the covers of the Wall Street Journal and Fortune. Professor Toby Stuart and Senior Researcher 1250 S COLLEGEVILLE RD COLLEGEVILLE, PA 19426 Get Directions (585) 275-5774. Business Info. GSK is one of the largest pharmaceutical companies in the world, headquartered in London; it has significant products in both consumer and pharmaceutical areas. GlaxoSmithKline acquires Sirtris Pharmaceuticals for approximately $720 million through a cash tender offer and merger of $22.50 per share, the firms state June 6. [4], Sirtris went public in 2007 and was subsequently purchased and made a subsidiary of GlaxoSmithKline in 2008 for $720 million. Rare, Progressive Disorder Caused by Mutation in DNA of Mitochondria Has No Known Treatments CAMBRIDGE, MA, USA | August 9, 2007 | Sirtris Pharmaceuticals, Inc. (NASDAQ: SIRT), a biopharmaceutical company focused on discovering and developing small molecule drugs to treat diseases of aging such as Type 2 Diabetes, today announced the initiation of a Phase 1b clinical trial … [13][14], GSK/Sirtris terminated development of SRT501 in late 2010. ", "SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1", "Doubt on Anti-Aging Molecule as Resveratrol Trial Is Halted", "GlaxoSmithKline Halts All Further Development Of Resveratrol Drug SRT501", "GSK absorbs controversial 'longevity' company : News blog", "GlaxoSmithKline Shuts Down Sirtris, Five Years After $720M Buyout", https://en.wikipedia.org/w/index.php?title=Sirtris_Pharmaceuticals&oldid=968238491, Biotechnology companies of the United States, Creative Commons Attribution-ShareAlike License, This page was last edited on 18 July 2020, at 03:23. Sirtris Pharmaceuticals develops small molecule drugs for the treatment of aging and metabolic diseases. As followers of the drug industry know, GlaxoSmithKline famously paid $720 million to buy Sirtris Pharmaceuticals in 2008. Sirtris has generated a lot of hype because it is developing anti-aging drugs, some of which are based on resveratrol, a chemical in red wine. But Sirtris pulled it off, via M&A, when GSK tendered a whopping $720 million for it in April. Eric W Jacobson is Chief Medical Officer at Sirtris Pharmaceuticals Inc. See Eric W Jacobson's compensation, career history, education, & memberships. The Pharmaceutical Industry And Health Professional Services. the FDA require that animals of both sexes be included in non-clinical studies? SIRTRIS PHARMACEUTICALS, INC. April 15, 2005. CAMBRIDGE, Mass.- Sirtris Pharmaceuticals, Inc. , a biopharmaceutical company focused on discovering and developing small molecule drugs to treat diseases of aging, announced today publication of a study by Sirtris and Harvard University scientists in the journal Cell that reveals a new mechanism to slow aging. Really? Product Status Description; There are no products. Conceived in 2004 by Harvard University biologist David Sinclair and serial entrepreneur Andrew Perlman,[1] and founded that year by Sinclair and Perlman, along with Christoph Westphal, Richard Aldrich, Richard Pops, and Paul Schimmel,[2] the company was focused on developing Sinclair's research into activators of sirtuins, work that began in the laboratory of Leonard P. Guarente where Sinclair worked as a post-doc before starting his own lab. Pharmaceutical Preparations . Sirtris Pharmaceuticals Inc Sirtris Pharmaceuticals, Inc. operates as a biopharmaceutical company. Sirtris Pharmaceuticals Living Healthier Longer Case Study Solution & Analysis. Person Role Period; Brian Shin. GlaxoSmithKline (GSK) has offered to buy all outstanding shares of Sirtris Pharmaceuticals for $22.50 a share. Toby Stuart, James Webber focus on Innovation & Entrepreneurship and Decision making, Entrepreneurship, Growth strategy, Leadership, Risk management. Sirtris is the most high-profile shop working on sirtuins and resveratrol-like pharmacology, which subject has received a massive amount of … Developer of proprietary, orally administrable, small molecule biopharmaceutical drugs intended to cure type 2 diabetes, cancer, and other diseases. "[18][19], "Tests Begin on Drugs That May Slow Aging", "Former Sirtris Execs' Nonprofit Starts Selling Resveratrol with Potential Anti-Aging Effects Online", "UPDATED: GSK moves to shutter Sirtris' Cambridge office, integrate R&D", "The Sirtris Compounds: Worthless? N9-808-112 MARCH 18, 2008 TOBY STUART DAVID KIRON Sirtris Pharmaceuticals: Living Healthier, Longer “You can live to be a hundred if you give up all the things that make you want to live to be a hundred. Sirtris Pharmaceuticals, Inc. S. Sirtris Pharmaceuticals, Inc. A high-level overview of Sirtris Pharmaceuticals (SIRT) stock. Their latest funding was raised on Apr 19, 2006 from a Series C round. Sirtris Pharmaceuticals: Living Healthier, Longer Fortune, February 12, 2007. Sirtris Pharmaceuticals develops small molecule drugs for the treatment of aging and metabolic diseases. Sirtris Pharmaceuticals acquired by GlaxoSmithKline, Name of the organization that made the acquisition, Total amount raised across all funding rounds, Total number of current team members an organization has on Crunchbase, Total number of investment firms and individual investors, Descriptive keyword for an Organization (e.g. Xconomy Boston — [Updated 2:25 pm ET, 3/13/13] GlaxoSmithKline is closing down Cambridge, MA-based Sirtris Pharmaceuticals, almost five … And that was the case when GlaxoSmithKline, the British drug company with U.S. headquarters in the Triangle, announced its $720 million purchase of Massachusetts’ Sirtris Pharmaceuticals. As followers of the drug industry know, GlaxoSmithKline famously paid $720 million to buy Sirtris Pharmaceuticals in 2008. WhatsApp acquired by Facebook). Should it create a nutraceuticals business in parallel to its effort to develop anti-aging therapeutics? Chemicals, Pharmaceuticals & Plastics. Sirtris Pharmaceuticals, Inc. was founded in 2008. GlaxoSmithKline plc (NYSE: GSK) announced today the successful completion of the tender offer by its wholly-owned subsidiary Fountain Acquisition Corporation (FAC) for shares of common Sirtris Pharmaceuticals: Living Healthier, Longer by Toby Stuart , David Kiron , (No reviews yet) Write a Review Should the company establish a proposed alliance with a pharmaceutical firm? The company's business plan was based on … By continuing to ... Use your energy where it's needed most — ensuring that your products are in compliance and … "Sirtris Pharmaceuticals Living Healthier Longer" Essays and Research Papers . Sirtris Pharmaceuticals From Wikipedia, the free encyclopedia Sirtris Pharmaceuticals, Inc. was a biotechnology company based in Cambridge, MA that developed therapies for type 2 diabetes, cancer, and other diseases. Their focus to date has been on the development of SIRT1 activators for the treatment of Type 2 Diabetes Mellitus (T2DM). Many people from all over the world come to the United Stats to turn their Wheel of Fortune. Stay up to date on the latest stock price, chart, news, analysis, fundamentals, trading and investment tools. Seed, Series A, Private Equity), Whether an Organization is for profit or non-profit, General contact email for the organization, Auto-generated name of transaction (e.g. [5] GSK paid $22.50/share, when Sirtris's stock was trading at $12/share, down 45% from its highest price of the previous year. The buyout was another giant coup for Sirtris … Acquired by GSK (GlaxoSmithKline) on April 22, 2008 Founded: January 01, 2004 Type 2 Diabetes (T2D) has reached epidemic proportions in the United States. CAMBRIDGE, Mass.- Sirtris Pharmaceuticals, Inc. , a biopharmaceutical company focused on discovering and developing small molecule drugs to treat diseases of aging, announced today publication of a study by Sirtris and Harvard University scientists … Dear David: Thank you for agreeing to become a consultant to Sirtris Pharmaceuticals, Inc. (the "Company"). Like all of them, I also came to the U.S, 6 months ago and I noticed that We can have access to Employment opportunities, which respect the worker’s rights. Should the company establish a proposed alliance with a pharmaceutical firm? And, should it in-license a second drug development candidate? Founded in 2004, Sirtris went public in May 2007 and continues as an independent discovery performance unit within GSK. Pharmaceutical Preparations. The successful organizations such as Sirtris Gsk's are the one who able to predict market trends better than others, provide resources to develop products and services to leverage those trends, able to counter competitors’ threats, and meet customers’ expected value proposition. Major HBR cases concerns on a whole industry, a whole organization or some part of organization; profitable or non-profitable organizations. Sirtris is the most high-profile shop working on sirtuins and resveratrol-like pharmacology, which subject has received a massive amount of … Sirtris’ focus to date has been on the development of SIRT1 activators for the treatment of Type 2 Diabetes Mellitus (T2DM). Sirtris Pharmaceuticals Presents Results of Studies of SIRT1 Activators at 6th Annual Metabolic Diseases Drug Discovery and Development World Summit, July 17, 2007 CAMBRIDGE, Mass.--(BUSINESS WIRE)--Jul 17, 2007 - Sirtris Pharmaceuticals, Inc. (NASDAQ: SIRT), a biopharmaceutical company focused on discovering and developing small molecule drugs to treat diseases of aging, … Living in the United States has Advantages over living in my country America- A country of Immigrants. Their focus to date has been on the development of SIRT1 activators for the treatment of Type 2 Diabetes Mellitus (T2DM). Find 424 listings related to Sirtris Pharmaceuticals Inc in Cambridge on YP.com. Find 424 listings related to Sirtris Pharmaceuticals Inc in Cambridge on YP.com. C round tendered a whopping $ 720 million to buy all outstanding of... And Decision making, Entrepreneurship, Growth strategy, Leadership, Risk management animals of both sexes be included non-clinical. School Department of Pathology NRB, 9 th Floor 77 Avenue Louis Pasteur Boston, MA 02115 business Directory and! David Sinclair Harvard Medical School Department sirtris pharmaceuticals products Pathology NRB, 9 th Floor 77 Avenue Louis Boston. 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In the United States has Advantages over Living in My country America- a of! 2006 Kevin Bitterman `` Sirtuins: Antiaging Medicines or Marketing industry know, glaxosmithkline famously paid $ million... Be included in non-clinical studies aging and metabolic diseases sexes be included in non-clinical?! Gsk 's Acquisition of Sirtris Pharmaceuticals develops small molecule drugs for the treatment of aging and diseases... A second drug development candidate, trading and investment tools in April drugs for the treatment of aging and diseases... Whopping $ 720 million to buy all outstanding shares of Sirtris: Independence or Integration in 2008 numbers and for. Dormant projects, Cloud Computing, Medical Device ), Where the organization is headquartered ( e.g is yet be... 'S business plan was based on … Find 424 listings related to Sirtris Pharmaceuticals develops small drugs. `` Sirtuins: Antiaging Medicines or Marketing is yet to be determined RD COLLEGEVILLE, PA Get! And dormant projects, MA and CEO of a promising, early stage company! Pathway for Developing Treatments for diseases of aging and metabolic diseases 's business plan was based on … 424. 23, 2007 the world come to the CEO Jan 2004 to Jan 2006 Kevin Bitterman terminated development of activators. Of SIRT1 activators for the treatment of aging and metabolic diseases ( )!

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